Genomic analysis shows a tight link between transcription factor dynamics and regulatory network architecture

1 Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA, 2 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MA, USA, 3 MRC Laboratory of Molecular Biology, Cambridge, UK and 4 Department of Computer Science, University of Chicago, Chicago, IL, USA 5 These authors contributed equally to this work * Corresponding authors. R Jothi or MM Babu, Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, MD A3-03, Research Triangle Park, NC 27709, USA. Tel.:þ 1 919 316 4557; Fax:þ 1 301 541 4311; E-mails: [email protected] or [email protected] 6 Present address: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA